Today, paying attention to the issue of resilience in order to reduce risks and damages caused by natural disasters in order to increase the livability of cities has received serious attention from managers, planners and those involved in urban issues. Due to its high population density and pressure on natural resources, the metropolis of Mashhad is very vulnerable to hazards such as land subsidence. Mashhad is facing a very high subsidence rate, which, given the importance of this city, seems essential to investigate and determine the cause of this phenomenon. In this study, using the radar interferometry (InSAR) method and processing Sentinel-1 satellite data in the SNAP software, the rate and pattern of subsidence in the Samen, 3 and 4 regions of Mashhad city were investigated during the years 2018 to 2023. The location of the Holy Shrine of Imam Reza (AS) and historical sites with a very high population density in the Samen region, as well as the location of the Mashhad railway station and the cargo terminal and wheat storage in regions three and four, adds to the importance of the issue. The results showed that the highest rate of subsidence occurred in 2021 with an amount of about −0.04 meters per year and the lowest in 2022. The railway station area and the historical centers of the Samen region show the highest risk. The findings indicate that the high population density and urban activities in these areas are effective factors in intensifying the subsidence rate. Accordingly, Mashhad urban management should prevent future damage to infrastructure and historical sites by continuous monitoring and implementing groundwater withdrawal control policies.